| 361 |
However, in a few apical patches the channel density was increased X 3, which could indicate channel clustering. Ca fluorescence imaging shows that application of T-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a two-fold greater effect in the dendrites than in the soma |
| 362 |
However, in a few apical patches the channel density was increased X 3, which could indicate channel clustering. Ca fluorescence imaging shows that application of T-channel antagonists reduces the Ca influx associated with backpropagating action potentials, and has a two-fold greater effect in the soma than in the dendrites |
| 363 |
However, in guinea pigs, a combination of high-speed imaging and simultaneous intracellular recordings showed that direct depolarization of the soma or dendrites never caused dendritic [Na+]i increases, suggesting that the climbing fiber-activated [Na+]i changes in the dendrites are due to Na+ entry through ligand-gated channels |
| 364 |
However, recordings in slices showed that D1 receptor activation can either inhibit or enhance evoked activity, depending on the level of membrane depolarization, by modulating an L-type Ca2+ conductance |
| 365 |
I M may contribute to a sag and rebound of voltage response to hyperpolarizing current steps |
| 366 |
Ia EPSPs are mediated largely by AMPA receptors (muscle afferents: |
| 367 |
Ia IPSPs are chloride mediated |
| 368 |
Ia IPSPs are readily affected by soma current or Cl- injection, indicating location at the soma or proximal dendrites |
| 369 |
Ia synapses are immunoreactive for GLU |
| 370 |
Identification of subunit mRNAs |
| 371 |
Ih conductance causes voltage attunuation and is more concentrated in dendrites than in soma |
| 372 |
Ih current: slowly developing hyperpolarisation-activated current with a threshold generally positive to resting potential and with a strongly voltage-dependent activation time constant. The current was Na+- and K+-sensitive, suppressed by external Cs+, and insensitive to Ba++. The Ih should be tonically active at rest, and may contribute to the oscillatory behaviour of the bulbar network |
| 373 |
Immunochemical evidence of glutamate as neurotransmitter in the terminals of parallel fibers |
| 374 |
Immunocytochemistry and in situ hybridisation showed that NMDAR1 was expressed in most CN neuronal types, including the fusiform cell apical dendrites. However, fusiform cell basal dendrites, which are the synaptic sites of cochlear nerve fibers, did not express NMDAR1 |
| 375 |
Immunohistochemical evidence shows that CaV1.3 (an L type channel; seeMembrane Properties Resource) is present in soma and all dendritic compartments in turtle motoneurons |
| 376 |
Immunohistochemical evidence shows that CaV1.3 is present in soma and all dendritic compartments in turtle motoneurons |
| 377 |
Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex |
| 378 |
Implied by current clamp recording of action potential at soma |
| 379 |
Implied by data on more proximal dendritic regions; still to be tested |
| 380 |
Implied by Glu released by other compartments of the mitral cell (Dale's law). Target (destination) is presumably PG cell dendrites in the glomerulus |
| 381 |
Implied by recording of fast prepotential. Dual patch recordings provide evidence for both backpropagating and forward-propagating impulses in the primary dendrite |
| 382 |
Implied from evidence that local interneurons colocalize FMRFamide and GABA |
| 383 |
Importance for membrane excitability of an GABAB receptor-activated inward-rectifying potassium current, sensitive to pertussis toxin and barium |
| 384 |
In a study of acutely isolated rat cells under whole cell recording across development states (Day 6 - Day 29), it was found that delayed rectifier currents decayed along a double-exponential time course and were 50% blocked by TEA (tetraethylammonium, a I(K) antagonist) at +30 mV at a concentration of about 1mM, as well as being partially blocked by 4-AP (4-aminopyridine). The current also appeared to increase over this development period. This increase was approximately 300% much larger in CA1 cells than in CA3 cells, with only approximately 50% |
| 385 |
In a study of acutely isolated rat cells under whole cell recording across development states (Day 6 - Day 29), it was found that delayed rectifier currents decayed along a double-exponential time course and were 50% blocked by TEA (tetraethylammonium, a K(DR) antagonist) at +30 mV at a concentration of about 1mM, as well as being partially blocked by 4-AP (4-aminopyridine). The current also appeared to increase over this development period. This increase was approximately 300% much larger in CA1 cells than in CA3 cells, with only approximately 50% |
| 386 |
In a study of acutely isolated rat cells under whole cell recording across development states (Day 6 - Day 29), it was found that delayed rectifier currents decayed along a double-exponential time course and were 50% blocked by TEA (tetraethylammonium, a K(DR) antagonist) at +30 mV at a concentration of about 1mM, as well as being partially blocked by 4-AP (4-aminopyridine). The current also appeared to increase over this development period. This increase was approximately 300% much larger in CA1 cells than in CA3 cells, with only approximately 50% |
| 387 |
In a study of acutely isolated rat cells under whole cell recording across developmental states (Day 6 - Day 29), I(A) was separated from I(K) by subtraction methods. It was found that I(A) was rapidly activated and inactivated and was 80% blocked by 4-AP (4-aminopyridine), but was insensitive to TEA (tetraethylammonium) and dendrotoxin (Klee et al, 1995). The current has also been shown to be modulated by K concentration (Eder et al, 1996), though this effect appears to be restricted to very early in development (Klee et al, 1997). |
| 388 |
In addition, IP3 gated ion channel; found in the autodendritic membrane |
| 389 |
In an immunocytochemical study in zebrafish 60-70% of cells showed KA receptor mediated labelling |
| 390 |
In an immunocytochemical study in zebrafish 60-70% of cells showed KA receptor mediated labelling |
| 391 |
In an immunocytochemical study in zebrafish all cells resulted in NMDA receptor mediated labelling |
| 392 |
In cell-attached patch-clamp recordings from the soma in guinea pig hippocampal slices, L-currents were found in 34% of the patches and found to have single channel conductances of 23-27 pS |
| 393 |
In cell-attached patch-clamp recordings from the soma in guinea pig hippocampal slices, L-currents were found in 34% of the patches and found to have single channel conductances of 23-27 pS (Johnston et al. 1992; |
| 394 |
In cell-attached patch-clamp recordings from the soma in guinea pig hippocampal slices, N-currents were found in 63% of the patches and found to have single channel conductances of 14 pS (Johnston et al. 1992; |
| 395 |
In cell-attached patch-clamp recordings from the soma in guinea pig hippocampal slices, T-currents were found in 72% of the patches and found to have single channel conductances of 8 pS |
| 396 |
In cell-attached patch-clamp recordings from the soma in guinea pig hippocampal slices, T-currents were found in 72% of the patches and found to have single channel conductances of 8 pS (Johnston et al. 1992, |
| 397 |
In cilia; K 0.5 for Ca activation is 5 uM; most of Ca activated current is carried by chloride and persists in the absence of Na and K; Cl channel inhibitor 3',5-dichlorodiphenylamine-2-carboxylate (300uM) reduces current 90%; other Cl-channel inhibitors were tested [SITS, DIDS, A9C, DPC, NPPB, DCDPC] |
| 398 |
In contrast, a study using radioactive in situ hybridization histochemistry looked at mRNA coding an NMDA glutamate binding protein and at NMDAR1 (an NMDAR subunit) expression and found heavy labeling for both in the pyramidal and polymorphic layers but little in the molecular layer |
| 399 |
In gold fish retinal bipolar cells, four currents are observed: Ca currents, voltage- and calcium-dependent K currents, and Ih current |
| 400 |
In mouse retinal bipolar cells, T-type Ca currents were recorded in soma, while L-type currents were recorded from axonal terminal |
