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Reckziegel G, Beck H, Schramm J, Elger CE, Urban BW (1998)
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1
With whole-cell recordings the properties of a voltage-dependent Na+ currents were investigated in 42 DGC acutely isolated from the resected hippocampus of 20 patients with therapy-refractory temporal lobe epilepsy (TLE) using the whole-cell patch-clamp technique.The kinetic properties contributed to a reduction of the Na+ currents during repetitive stimulation that was more pronounced with higher stimulation frequencies and also showed a dependence on the holding potential