| 1 |
A-type K+ channel block causes increased back-propagation of action potentials |
| 2 |
A-type K+ channel block makes dendrites more excitable |
| 3 |
Aß causes increased Ca++ influx by activation of L-type Ca++ channels |
| 4 |
Aß influences neuronal excitability by effects on dendritic ion channels |
| 5 |
Back-propagating action potentials influence LTP and LTD |
| 6 |
Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable |
| 7 |
Increased excitability can increase Ca++ influx causing synaptic effects and excitotoxicity |
| 8 |
Loss/alteration of dendritic spines in early Alzheimer's |
| 9 |
Pathological plaques and tangles in Alzheimer's are primarily in and around dendrites |
| 10 |
Shepherd Dendritic Hypothesis |
| 11 |
Soluble Aß affects CA1 Hippocampal neurons by action on A-type channels |