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The Schaeffer collateral/commissural pathway elicits EPSPs in CA1 that have a large AMPA receptor-mediated component that can be blocked by CNQX Show
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Reviewed in Show
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EM showed colocalization at axodendritic asymmetric synapses within the CA1 subfield of rat hippocampus. AMPA/NMDA receptor colocalization was found in non-GABAergic dendritic shafts as well as dendritic spines, suggesting that excitatory neuronal transmission in CA1 neurons may generally involve activation of both NMDA and AMPA receptor subunits at a single synapse Show
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Using outside-out patches and a fast application system the properties and distribution of synaptic glutamate receptors an approximately twofold increase in AMPA-mediated current was observed in the dendritic region that receives a uniform density of Schaffer collateral input (100-250um from soma) Show
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