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Na impulses may underly "fast prepotentials" that boost distal EPSPs Show
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Na action potentials support backpropagating impulses Show
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and can activate Ca action potentials Show
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Patch recordings yield an approximate channel density of 28 pS/micron^2 in juvenile rats < 4 wks of age, rising to 61 pS/micron^2 in older rats. Channel density was similar in other dendritic compartments Show
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However, channel density varied widely in the proximal compartment, possibly indicating the presence of hot spots. Show
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Inactivation of dendritic Na channel contributes to the attenuation of activity-dependent backpropagation of APs Show
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Slow inactivation of sodium channels in dendrites and soma will modulate neuronal excitability in a way that depends in a complicated manner on the resting potential and previous history of action potential firing Show
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Single action potential backpropagations show dichotomy of either strong attenuation (26-42%) or weak attenuation (71-87%). The dichotomy seems to be conferred primarily by differences in distribution, density, etc. of voltage dependent sodium and potassium channel (A-type, especially ) along the somatodendritic axis Show
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