Pathological mechanism

Data

Name Abeta increase in A-type K+ current is caused by modulation of Kv4 subunit expression

Description

Hypothesis

Extracelular pathological element beta Amyloid (1-40) Show Other

Intracelular pathological element

Pathological action Increases Show Other

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s) I A Show Other

Pharmacological Agent brefeldin A Show Other cycloheximide Show Other

Pharmacological Action Blocks Show Other

Brain region Cerebellum cortex Show Other

Neuron Cerebellum interneuron granule GLU cell Show Other

Cell model

Cellular compartment

PubMed ID 16271805

Citation

AlzWeb

Notes Amyloid beta peptide as a physiological modulator of neuronal 'A'-type K+ current.Plant LD, Webster NJ, Boyle JP, Ramsden M, Freir DB, Peers C, Pearson HA. Neurobiol Aging. 2006 Nov;27(11):1673-83.

Pathology

Stage

Question

Claim