Pathological mechanism

Data

Name Abeta decreases dedritic spine number and alters dendritic spine morpholology

Description

Hypothesis

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Induces Show Other

Process Dendritic Spine Loss Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron Cerebellum Purkinje GABA cell Show Other

Cell model

Cellular compartment Dendrite Show Other

PubMed ID 18438727

Citation

AlzWeb

Notes A review of loss or alteration of dendritic spines induced by the amyloid beta (Abeta) peptide in the context of AD. Dendritic spine loss and synaptic alterations in Alzheimer's disease.Knobloch M, Mansuy IM. Mol Neurobiol. 2008 Feb;37(1):73-82.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Shepherd Dendritic Hypothesis Show Other