Pathological mechanism

Data

Name Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals

Description

Hypothesis

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process

Process action

Transmitter(s) Acetylcholine Show Other

Receptor(s) Nicotinic Show Other

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

Cell model

Cellular compartment

PubMed ID

Citation

AlzWeb 16987213

Notes Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals, causing failure of nicotine-dependent enhancement of synaptic efficacy at Schaffer-collateral CA1 synapses of AD11 anti-nerve growth factor transgenic mice. This takes place possibly through calcium signalling via presynaptic alpha7 nicotine acetylcholine receptors. Sola E, Capsoni S, Rosato-Siri M, Cattaneo A, Cherubini E. Eur J Neurosci. 2006 Sep;24(5):1252-64

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim