Pathological mechanism

Data

Name Regulation of back-propagating action potentials in hippocampal neurons.

Description

Hypothesis Dendritic hypothesis Show Other

Extracelular pathological element

Intracelular pathological element protein kinase C Show Other

Pathological action Inhibits Show Other

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s) I Sodium Show Other

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

Cell model

Cellular compartment Apical dendrite Show Other

PubMed ID 10811726

Citation

AlzWeb

Notes Johnston, D., Hoffman, D. A., Colbert, C. M., & Magee, J. C. (1999). Regulation of back-propagating action potentials in hippocampal neurons. Current Opinion in Neurobiology, 9(3), 288-292. Protein kinase C modulates the slow recovery from inactivation of Na+ channels in apical dendrites of hippocampal CA1 pyramidal neurons. Dendritic, A-type K+ channels have been found to be modulated by protein kinases A and C and by mitogen-activated protein kinase.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Back-propagating action potentials influence LTP and LTD Show Other