Pathological mechanism

Data

Name LTP requires BDNF and is associated with cytoskeleton-associated protein

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element BDNF (Brain-derived neurotrophic factor) Show Other

Intracelular pathological element Cytoskeleton-associated protein (Arc) Show Other

Pathological action Is Required For Show Other

Process LTP Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment

PubMed ID 17765733

Citation

AlzWeb

Notes Bramham, C. R. (2007). Control of synaptic consolidation in the dentate gyrus: Mechanisms, functions, and therapeutic implications. Progress in Brain Research, 163, 453-471. Dysregulation of BDNF synthesis and Arc function, specifically within the dentate gyrus, is linked to behavioral symptoms and cognitive deficits in animal models of depression and Alzheimer's disease.

Pathology Alzheimer Show Other

Stage Early Show Other

Question Exclude - biochemistry

Claim