Pathological mechanism

Data

Name Nicotine desensitize alpha7 nACh receptors and facilitates LTP

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element Nicotine Show Other

Intracelular pathological element

Pathological action Potentiates Show Other

Process LTP Show Other

Process action Desensitizes Show Other

Transmitter(s)

Receptor(s) Nicotinic Show Other

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID 16115208

Citation

AlzWeb

Notes Yamazaki, Y., Jia, Y., Hamaue, N., & Sumikawa, K. (2005). Nicotine-Induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction. Eur J Neurosci, 22(4), 845-860. Suggest that nicotine promotes the induction of LTP by diminishing inhibitory influences on NMDA responses while suppressing the ACh-mediated mechanisms. These ACh-independent mechanisms probably contribute to the nicotine-induced cognitive enhancement observed in the presence of cholinergic deficits, such as those in Alzheimer's disease patients.

Pathology Alzheimer Show Other

Stage Late Show Other

Question

Claim