Pathological mechanism

Data

Name Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Reduces Show Other

Process Dendritic spine motility Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent Rolipram Show Other

Pharmacological Action Blocks Show Other

Brain region Hippocampus CA1 Show Other

Neuron Hippocampus CA1 pyramidal GLU cell Show Other

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID 16962789

Citation

AlzWeb

Notes Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons.Shrestha BR, Vitolo OV, Joshi P, Lordkipanidze T, Shelanski M, Dunaevsky A. Mol Cell Neurosci. 2006 Nov;33(3):274-82. Exposure of hippocampal neurons to sub-lethal levels of Abeta decreased spine density, increased spine length and subdued spine motility. The effect of Abeta on spine density was reversible. Moreover, Abeta's effect on dendritic spine density was blocked by rolipram, a phosphodiesterase type IV inhibitor.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Loss/alteration of dendritic spines in early Alzheimer's Show Other