Pathological mechanism

Data

Name NGF restores dendritic spine density in Layer V pyramidal neurons

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element Nerve Growth Factor (NGF) Show Other

Intracelular pathological element

Pathological action Increases Show Other

Process Dendritic spine density Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Visual cortex Show Other

Neuron Neocortex L5/6 pyramidal GLU cell Show Other

Cell model Golgi impregnation - Animal post-mortem brains Show Other

Cellular compartment Distal apical dendrite Show Other

PubMed ID 1723258

Citation

AlzWeb

Notes Mervis, R. F., Pope, D., Lewis, R., Dvorak, R. M., & Williams, L. R. (1991). Exogenous nerve growth factor reverses age-related structural changes in neocortical neurons in the aging rat. A quantitative golgi study. Annals of the New York Academy of Sciences, 640, 95-101. NGF treatment restored dendritic spine densities to those seen in young controls on terminal tip segments ("plastic" regions). Internal branch segments ("nonplastic" regions) showed no response to NGF.

Pathology

Stage

Question

Claim Loss/alteration of dendritic spines in early Alzheimer's Show Other