Pathological mechanism

Data

Name Abeta (1-42) increases dopamine release in the prefrontal cortex

Description

Hypothesis Nicotinic Receptor Hypothesis Show Other

Extracelular pathological element Beta-amyloid (1-42) Show Other

Intracelular pathological element

Pathological action Increases Show Other

Process

Process action

Transmitter(s) Dopamine Show Other

Receptor(s)

Channel(s)

Pharmacological Agent alpha7 nicotinic receptor antagonists Show Other

Pharmacological Action Blocks Show Other

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 17935702

Citation

AlzWeb

Notes In the presence of tetrodotoxin, Abeta(1-42) at 100 nM evoked the release of dopamine to approximately 170% of basal levels in the pre-frontal cortex. The Abeta(1-42)-evoked dopamine release was sensitive to antagonists of alpha7 nicotinic receptors.

Pathology

Stage

Question

Claim