Pathological mechanism

Data

Name Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.

Description

Hypothesis

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Reduces Show Other

Process Glutamatergic Synapse Activity Show Other

Process action

Transmitter(s) Glutamate Show Other

Receptor(s) Muscarinic Show Other

Channel(s) I L high threshold Show Other

Pharmacological Agent Atropine Show Other Calcicludine Show Other Pirenzepine Show Other

Pharmacological Action Blocks Show Other

Brain region

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID 17171714

Citation

AlzWeb

Notes Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.Santos-Torres J, Fuente A, Criado JM, Riolobos AS, Heredia M, Yajeya J. BetaA effect was blocked by calcicludine (50 nM), a selective antagonist of L-type calcium channels, and also by blocking muscarinic receptors with atropine (5 muM) or pirenzepine (1 microM), a more specific M1-receptor blocker.

Pathology

Stage

Question

Claim