Pathological mechanism

Data

Name ACh Esterase inhibitors decrease Abeta production by influencing APP processing

Description

Hypothesis Nicotinic Receptor Hypothesis Show Other

Extracelular pathological element ACh Esterase inhibitors Show Other

Intracelular pathological element

Pathological action Reduces Show Other

Process Abeta production Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 16772751

Citation

AlzWeb

Notes AChE inhibitors influence APP processing and attenuate Abeta-induced toxicity via mechanisms including interruption of the production of Abeta, alteration of the levels of Abeta 1-50 and 1-52, and formation of the soluble form of APP. Some of these effects seem to occur independently of nicotinic receptors Mechanisms behind the neuroprotective actions of cholinesterase inhibitors in Alzheimer disease.Nordberg A.Alzheimer Dis Assoc Disord. 2006 Apr-Jun;20(2 Suppl 1):S12-8

Pathology Alzheimer Show Other

Stage Late Show Other

Question Exclude - Biochemistry

Claim