Pathological mechanism

Data

Name Nicotine increases APP and APLP2 gene expression

Description

Hypothesis Nicotinic Receptor Hypothesis Show Other

Extracelular pathological element Nicotine Show Other

Intracelular pathological element

Pathological action Increases Show Other

Process APP/APLP2 gene expression Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent Mecamylamine Show Other

Pharmacological Action Decreases Show Other

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment

PubMed ID 16707114

Citation

AlzWeb

Notes Nicotine treatment facilitates the increase in the expression of mRNA and protein of the APP and APLP2 genes in rat brain (hippocampus and amygdala) and SH-SY5Y neuroblastoma cells. Co-treatment with mecamylamine (an antagonist of nicotinic acetylcholine receptors) attenuated the stimulating effect of nicotine on APP and APLP2 expression.Nicotine modulates expression of amyloid precursor protein and amyloid precursor-like protein 2 in mouse brain and in SH-SY5Y neuroblastoma cells.Gutala R, Wang J, Hwang YY, Haq R, Li MD. Brain Res. 2006 Jun 6;1093(1):12-9.

Pathology Alzheimer Show Other

Stage Late Show Other

Question Exclude -Biochemistry, Cell Expression

Claim