Pathological mechanism

Data

Name Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD

Description

Hypothesis Nicotinic Receptor Hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process Wnt/beta-catenin signalling Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent Nicotine Show Other

Pharmacological Action Protects Show Other

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 18652670

Citation

AlzWeb

Notes Abeta binds to the extracellular cysteine-rich domain of the Frizzled receptor (Fz) inhibiting Wnt/beta-catenin signaling. Cross-talk with other signaling cascades that regulate Wnt/beta-catenin signaling, including the activation of M1 muscarinic receptor and PKC, the use of Ibuprofen-ChE bi-functional compounds, PPAR alpha, gamma agonists, nicotine and some antioxidants, results in neuroprotection against Abeta. Inestrosa, N. C., & Toledo, E. M. (2008). The role of wnt signaling in neuronal dysfunction in alzheimer's disease. Molecular Neurodegeneration, 3(1), 9.

Pathology

Stage

Question

Claim