Pathological mechanism

Data

Name Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice

Description

Hypothesis Dendritic Spine Hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Reduces Show Other

Process Dendritic spine density Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model Golgi impregnation - Animal post-mortem brains Show Other

Cellular compartment Dendrite Show Other

PubMed ID 18632740

Citation

AlzWeb

Notes Three-dimensional analysis of 21 507 dendritic spines in the dentate gyrus, a region crucial for learning and memory, revealed a substantial decrease in the frequency of large spines in plaque-free regions of APP/PS1 mice. Plaque-related dendrites also show striking alterations in spine density and morphology. However, plaques occupy only 3.9% of the molecular layer volume. Because large spines are considered to be the physical traces of long-term memory, widespread decrease in the frequency of large spines likely contributes to the cognitive impairments observed in this AD model. Knafo, S., Alonso-Nanclares, L., Gonzalez-Soriano, J., Merino-Serrais, P., Fernaud-Espinosa, I., Ferrer, I., et al. (2008). Widespread changes in dendritic spines in a model of alzheimer's disease. Cerebral Cortex

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim Loss/alteration of dendritic spines in early Alzheimer's Show Other