Pathological mechanism

Data

Name Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla

Description

Hypothesis Synapse Loss Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Induces Show Other

Process Synapse Loss Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model Human Post-mortem Study Show Other

Cellular compartment

PubMed ID 1789684

Citation

AlzWeb

Notes Only weak correlations between psychometric indices and plaques and tangles, but the density of neocortical synapses reveals very powerful correlations withpsychological assays in AD/normal subjects. Midfrontal and inferior parietal synapse density, plus inferior parietal plaque has a correlation coefficient of 0.96 with Mattis's Dementia Rating Scale. Plaque density contributed only 26% of that strength.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim