Pathological mechanism

Data

Name Abeta inhibits LTP through TNFalpha

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element TNFalpha Show Other

Pathological action Inhibits Show Other

Process LTP Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model Brain slice preparations Show Other

Cellular compartment

PubMed ID 17956317

Citation

AlzWeb

Notes Ligands that neutralize TNFalpha or genetic knockout of TNF-R1s (type-1 TNFalpha receptors) prevented Abeta-triggered inhibition of LTP in hippocampal slices. Similarly, antibodies to alphav-containing integrins abrogated LTP block by Abeta.Mild cognitive impairment in early AD (Alzheimer's disease) may be due to synaptic dysfunction long before widespread synaptic loss and neurodegeneration occurs. Rowan, M. J., Klyubin, I., Wang, Q., Hu, N. W., & Anwyl, R. (2007). Synaptic memory mechanisms: Alzheimer's disease amyloid beta-peptide-induced dysfunction. Biochemical Society Transactions, 35(Pt 5), 1219-1223.

Pathology Alzheimer Show Other

Stage Early Show Other

Question

Claim