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Neuron
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Neocortex M1 L6 pyramidal corticothalamic GLU cell
Cajal, S. Ramon y (1911). Reprinted and translated by Swanson and Swanson, Oxford University Press, 1995.
111
 Neuronal Receptors (25)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Middle basal dendrite Glutamate -----
2 Yes Proximal basal dendrite Glutamate -----
3 Yes Axon hillock GabaA Chandelier Cell Interneuron terminals (T)
4 Yes Axon hillock GabaB Chandelier Cell Interneuron terminals (T)
5 Yes GabaA
6 Yes GabaB
7 Yes Proximal apical dendrite GabaA The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
8 Yes Proximal apical dendrite GabaB The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
9 Yes Middle apical dendrite GabaA The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
10 Yes Middle apical dendrite GabaB The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
11 Yes Distal apical dendrite GabaA The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
12 Yes Distal apical dendrite GabaB The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
13 Yes Axon terminal D1 Dual whole-cell recordings in connected cell pairs suggested that attenuation of local horizontal excitation by dopamine is through D1 actions at a presynaptic site
14 Yes Distal apical dendrite 5-HT2 Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex
15 Yes Middle apical dendrite 5-HT2 Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex
16 Yes Proximal apical dendrite 5-HT2 Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex
17 Yes Soma 5-HT2 Immunolabeling was observed in soma and dendrites of layer V pyramidal cells in the frontal cortex
18 Yes Soma GabaA Basket Cell Interneuron terminals (T) The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
19 Yes Soma GabaB Basket Cell Interneuron terminals (T) The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
20 Yes Distal apical dendrite Glutamate ----- Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points
21 Yes Middle apical dendrite Glutamate ----- Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points
22 Yes Proximal apical dendrite Glutamate ----- Recordings using infrared-guided laser stimulation combined with whole cell recordings revealed a highly nonuniform distribution. Hot spots, with amplitude and integral of glutamate-evoked responses three times larger than responses evoked at neighboring sites, were detected. It appeared that the larger responses evoked resulted from an increase in activation of both AMPA and NMDA receptors. There was no correlation with branch points
23 Yes Distal basal dendrite Glutamate -----
24 Yes Soma NMDA The rate of NMDAR channel opening was studied in response to depolarisations at different times after brief (1 ms) and sustained (4.6 s) applications of glutamate to nucleated patches from neocortical pyramidal neurons
25 Yes Distal apical dendrite NMDA Apical dendrites of L6 pyramidal neurons in somatosensory cortex are similar to L5 and L2/3 in that they includeNMDA-dependent electrogenesis
 Neuronal Currents (41)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Middle apical dendrite I N Dendritic fluorescence imaging showed that Ca2+ channels of several subtypes mediated the AP-evoked fluorescence transient in the proximal (100-170 microns) apical dendrite. The fluorescence resulted from Ca2+ entry through L, N, and P-type channels, and through Ca2+ channels (R-type) not sensitive to L-, N- and P-type Ca2+ channel blockers
2 Yes Axon hillock I Na,t
3 Yes Axon hillock I K
4 Yes Axon fiber I Na,t
5 Yes Axon terminal I N
6 Yes Distal apical dendrite I K
7 Yes Distal apical dendrite I A
8 Yes Middle apical dendrite I K
9 Yes Middle apical dendrite I A
10 Yes Proximal apical dendrite I K
11 Yes Distal apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
12 Yes Distal apical dendrite I h A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course
13 Yes Middle apical dendrite I h A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course
14 Yes Proximal apical dendrite I h A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course
15 Yes Soma I h A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course
16 Yes Distal basal dendrite I h The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance
17 Yes Middle basal dendrite I h The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance
18 Yes Proximal basal dendrite I h The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. The basal dendrites were practically devoid of this conductance
19 Yes Soma I A
20 Yes Proximal apical dendrite I A
21 Yes Soma I K,Ca Ca2+-activated K+ currents were studied using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons
22 Yes Soma I Na,t
23 Yes Soma I K
24 Yes Soma I Na,p This persistant conductance may be activated by the NMDA receptor depolarization, providing a mechanism for graded, voltage dependent EPSP amplification
25 Yes Distal apical dendrite I p,q Many authors have described the activation of dendritic voltage activated Ca channels
26 Yes Distal apical dendrite I Na,p This persistant conductance may be activated by the NMDA receptor depolarization, providing a mechanism for graded, voltage dependent EPSP amplification
27 Yes Distal apical dendrite I Na,t
28 Yes Middle apical dendrite I Na,p This persistant conductance may be activated by the NMDA receptor depolarization, providing a mechanism for graded, voltage dependent EPSP amplification
29 Yes Middle apical dendrite I Na,t
30 Yes Middle apical dendrite I p,q Many authors have described the activation of dendritic voltage activated Ca channels
31 Yes Proximal apical dendrite I Na,p This persistant conductance may be activated by the NMDA receptor depolarization, providing a mechanism for graded, voltage dependent EPSP amplification
32 Yes Proximal apical dendrite I Na,t
33 Yes Proximal apical dendrite I p,q Many authors have described the activation of dendritic voltage activated Ca channels
34 Yes Middle apical dendrite I L high threshold Dendritic fluorescence imaging showed that Ca2+ channels of several subtypes mediated the AP-evoked fluorescence transient in the proximal (100-170 microns) apical dendrite. The fluorescence resulted from Ca2+ entry through L, N, and P-type channels, and through Ca2+ channels (R-type) not sensitive to L-, N- and P-type Ca2+ channel blockers
35 Yes Middle apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
36 Yes Proximal apical dendrite I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
37 Yes Proximal apical dendrite I L high threshold Dendritic fluorescence imaging showed that Ca2+ channels of several subtypes mediated the AP-evoked fluorescence transient in the proximal (100-170 microns) apical dendrite. The fluorescence resulted from Ca2+ entry through L, N, and P-type channels, and through Ca2+ channels (R-type) not sensitive to L-, N- and P-type Ca2+ channel blockers
38 Yes Proximal apical dendrite I N Dendritic fluorescence imaging showed that Ca2+ channels of several subtypes mediated the AP-evoked fluorescence transient in the proximal (100-170 microns) apical dendrite. The fluorescence resulted from Ca2+ entry through L, N, and P-type channels, and through Ca2+ channels (R-type) not sensitive to L-, N- and P-type Ca2+ channel blockers
39 Yes Soma I Calcium Using calcium imaging, calcium waves in layer 2/3 and layer 5 neocortical somatosensory pyramidal neurons were examined in slices from 2- to 8-week-old rats
40 Yes Soma I CAN using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels
41 Yes Soma I L high threshold using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels
 Neuronal Transmitters (3)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal Glutamate Spiny Neuron: Ded and Thalamic Relay Neuron: Ded and Superficial Pyramidal Neurons From cerebral cortex
2 Yes Soma Glutamate Dual whole-cell recordings in acute slices showed that kainate receptors located on presynaptic interneuron terminals can be activated by glutamate released from the somatodendritic compartment of the postsynaptic pyramidal cells
3 Yes Proximal apical dendrite Glutamate Dual whole-cell recordings in acute slices showed that kainate receptors located on presynaptic interneuron terminals can be activated by glutamate released from the somatodendritic compartment of the postsynaptic pyramidal cells
Other categories referring to Neocortex M1 L6 pyramidal corticothalamic GLU cell
Neuronal Structure.Neurons   (1)
Revisions: 5
Last Time: 2/8/2018 11:28:56 AM
Reviewer: System Administrator
Owner: System Administrator