OrDB
Neuron
  Data
Olfactory bulb main interneuron periglomerular GABA cell
Cajal (1911) Histology of the Nervous System of Man and Vertebrates (p537, English translation, 1995)
159,394
130
 Neuronal Receptors (19)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Soma Gaba Primary culture In primary culture, GABA and glycine exert inhibitory actions on olfactory bulb neurons, mitral/tufted cells, granule and periglomerular cells
2 Yes Soma Kainate In an immunocytochemical study in zebrafish 60-70% of cells showed KA receptor mediated labelling
3 Yes Soma NMDA In an immunocytochemical study in zebrafish all cells resulted in NMDA receptor mediated labelling
4 Yes Soma mGluR1
5 Yes Soma mGluR2
6 Yes Soma mGluR3
7 Yes Proximal equivalent dendrite Serotonin
8 Yes Proximal equivalent dendrite mGluR1
9 Yes Proximal equivalent dendrite mGluR2
10 Yes Proximal equivalent dendrite mGluR3
11 Yes Soma Gaba Possibly from other interneurons in the glomerular layer. It was shown that stimulation of PG cells results in self-inhibition: release of GABA from an individual PG cell activates GABA(A) receptors on the same neuron
12 Yes Soma Glycine primary culture Glycine and GABA exert inhibitory actions on olfactory bulb neurons, mitral/tufted cells, granule and periglomerular cells).
13 Yes Soma Nicotinic culture cells Application of acetylcholine (ACh) evoked concentration-dependent whole-cell currents
14 Yes Distal equivalent dendrite Cholinergic Receptors In triads made up of (i) a cholinergic axon, (ii) one or several periglomerular or granule cell dendrites, and (iii) usually one relay cell dendrite, asymmetric cholinergic synapses were selectively focused on dendrites (gemmules and spines) of periglomerular or granule cells.
15 Yes Soma Cholinergic Receptors primary culture Periglomerular cells respond to microapplication of GABA, acetylcholine, norepinephrine and glycine with the activation of distinct ionic currents.
16 Yes Distal equivalent dendrite AMPA
17 Yes Distal equivalent dendrite NMDA
18 Yes Distal equivalent dendrite GabaA
19 Yes Distal equivalent dendrite GabaB
 Neuronal Currents (11)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Soma I Na,t Depolarisations beyond -40 mV activated a fast transient TTX-sensitive inward current. Once activated, INa declined exponentially to zero following a single exponential. The underlying conductance showed a sigmoidal activation between -40 and +30 mV, with half activation at -17.4 mV and a maximal value of 9.7 nS per neurone. The steady-state inactivation was complete at -30 mV and completely removed at -90 mV, with a midpoint at -56 mV. The activation process could be adequately described by third order kinetics, with time constants ranging from 260 microseconds at -20 mV to 70 microseconds at +50 mV.
2 Yes Soma I Calcium Electrophysiological classification of juxtaglomerular neurons: bursting and standard firing. In contrast to the standard firing neurons, bursting neurons produced a calcium-channel-dependent low-threshold spike (LTS) when depolarized either by current injection or by spontaneous or evoked postsynaptic potentials. Bursting neurons also could oscillate spontaneously. Most bursting cells were either periglomerular cells or external tufted cells. Based on their mode of firing and placement in the bulb circuit, these bursting cells are well situated to drive synchronous oscillations in the olfactory bulb. LVA (low voltage-activated) Ca++ channel may be involved in LTS.
3 Yes Soma I h histological experiments found Ih expressed in many olfactory bulb cell types including periglomerular cells.
4 Yes Middle equivalent dendrite I h histological experiments found Ih expressed in many olfactory bulb cell types including periglomerular cells.
5 Yes Soma I A mRNA of A-channel subunit Kv4.3 is expressed predominantly in periglomerular cells. (In contrast, that of Kv4.2, also of A-channel, is expressed predominantly in granule cells)
6 Yes Soma I h Ih current: slowly developing hyperpolarisation-activated current with a threshold generally positive to resting potential and with a strongly voltage-dependent activation time constant. The current was Na+- and K+-sensitive, suppressed by external Cs+, and insensitive to Ba++. The Ih should be tonically active at rest, and may contribute to the oscillatory behaviour of the bulbar network
7 Yes Soma I p,q The distribution of the P-type calcium channel in the mammalian central nervous system has been demonstrated immunohistochemically by using a polyclonal specific antibody. Electron microscopic localization revealed labeled patches of plasma membrane on the soma, main dendrites, spiny branchlets, and spines; portions of the smooth endoplasmic reticulum were also labeled. Strong labeling was present in the periglomerular cells of the olfactory bulb, ...etc
8 Soma I Na,t PG cells closely resembled previously described periglomerular cells in their morphology. During current clamp recording these neurons were characterized by their lack of action potentials upon depolarization. Consistent with these results no Na+ currents could be elicited in voltage clamp experiments. Two types of outward K+ currents were distinguished: one which inactivated and one which did not.
9 Yes Soma I K Re: PG cells: Two types of outward K+ currents were distinguished: one which inactivated and one which did not.
10 Yes Distal equivalent dendrite I h histological experiments found Ih expressed in many olfactory bulb cell types including periglomerular cells.
11 Yes Proximal equivalent dendrite I h histological experiments found Ih expressed in many olfactory bulb cell types including periglomerular cells.
 Neuronal Transmitters (8)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Distal equivalent dendrite Gaba GAD-positive staining gemmules (i.e., spines) of periglomerular cells also formed reciprocal dendrodentritic synaptic contacts with mitral/tufted cell dentrites.
2 Yes Soma Gaba GAD-positive staining
3 Yes Distal equivalent dendrite NO Using double-staining techniques, the distribution of NADPH-diaphorase (ND)- and nitric oxide synthase (NOS)-positive cells was compared in the periglomerular region of typical and atypical rat olfactory glomeruli. The number of ND/NOS-stained periglomerular cells was much higher (P < 0.001) in typical than in atypical glomeruli.
4 Yes Distal equivalent dendrite Dopamine Dopaminergic subdivision of the periglomerular interneurons throughout classes of vertebrates.
5 Yes Axon terminal Dopamine
6 Yes Axon terminal Gaba
7 Yes Axon terminal NO
8 Yes Middle equivalent dendrite Gaba
Other categories referring to Olfactory bulb main interneuron periglomerular GABA cell
Interneurons Connectivity.Interneuron   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
ABA Genes.Neuron   (1)
Neuronal Structure.Neurons   (1)
Revisions: 7
Last Time: 12/18/2015 2:50:31 PM
Reviewer: Luis Marenco
Owner: Buqing Mao