Pathological mechanism

Data

Name Inhibition of I_L impairs LTP in CA1 in vivo

Description

Hypothesis LTP hypothesis Show Other

Extracelular pathological element beta Amyloid Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process

Process action

Transmitter(s)

Receptor(s) NMDA Show Other

Channel(s) I L high threshold Show Other

Pharmacological Agent Verapamil Show Other

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment

PubMed ID 12650963

Citation Inhibition of L-type voltage dependent calcium channels causes impairment of long-term potentiation in the hippocampal CA1 region in vivo. Show Other

AlzWeb

Notes A reduced level of LTP could still be recorded following co-administration of verapamil and D-AP5. The level of LTP recorded was similar to that observed in the presence of either verapamil (10 mg/kg) or D-AP5 alone. These results suggest that activation of the NMDA receptor/channel and L-type VDCCs are involved in the induction of LTP in area CA1 in vivo. However, it appears that activation of other receptor/channels may also play a role in this form of LTP. (Freir DB, Herron CE 2003)

Pathology Alzheimer Show Other

Stage Early Show Other

Question Exclude - No pathology

Claim