Pathological mechanism

Data

Name Postsynaptic calcium concentration in aging neurons is closely associated with altered plasticity.

Description

Hypothesis Dendritic Hypothesis - Ca++ currents Show Other

Extracelular pathological element

Intracelular pathological element

Pathological action

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s) I L high threshold Show Other

Pharmacological Agent

Pharmacological Action

Brain region Hippocampus CA1 Show Other

Neuron

Cell model

Cellular compartment

PubMed ID 11739583

Citation

AlzWeb

Notes ... the selective L-VSCC (L-type volt. sens. Ca chan.) agonist Bay K8644 increased the afterhyperpolarization and mimicked the depressive effects of aging on FF (frequency facilititation) in young-adult neurons. Thus, during physiologically relevant firing patterns in aging neurons, postsynaptic Ca(2+) elevation is closely associated with altered neuronal plasticity. Moreover, selectively increasing postsynaptic L-VSCC activity, as occurs in aging, negatively regulated a form of short-term plasticity that enhances synaptic throughput. Together, the results elucidate novel processes that may contribute to impaired cognitive function in aging (Thibault O, et al. 2001).

Pathology Alzheimer Show Other

Stage Early Show Other

Question Exclude - No pathology

Claim