Pathological mechanism

Data

Name Donepezil modulates potassium channels

Description

Hypothesis Dendritic Hypothesis - K+ current Show Other

Extracelular pathological element

Intracelular pathological element

Pathological action

Process

Process action

Transmitter(s)

Receptor(s)

Channel(s) I K Show Other

Pharmacological Agent Donepezil Show Other

Pharmacological Action Modulates Show Other

Brain region

Neuron

Cell model Isolated neurons of the land snake Helix Show Other

Cellular compartment

PubMed ID 16485632

Citation

AlzWeb Donepezil

Notes This work was the first to show different effects of donepezil on two different types of potassium channels (I K(DR) and I K(A)) of molluscan neurons. At a low concentration (5 uM), the drug suppressed I K(DR) but augmented I K(A); at higher concentrations (10-100 uM), it reduced both current types. The ability of donepezil to reduce I K(DR) at low concentrations suggests the drug ability to prevent neurodegeneration in Alzheimer's disease. (Solntseva et al., 2005)

Pathology Alzheimer Show Other

Stage

Question

Claim Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable Show Other A-type K+ channel block makes dendrites more excitable Show Other