Pathological mechanism

Data

Name Synaptic integration is disrupted in an AD mouse model

Description

Hypothesis

Extracelular pathological element Beta amyloid plaques Show Other

Intracelular pathological element

Pathological action Inhibits Show Other

Process Evoked Synaptic response Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model

Cellular compartment

PubMed ID 15140924

Citation Cortical Synaptic Integration In Vivo Is Disrupted by Amyloid-{beta} Plaques Show Other

AlzWeb

Notes The evoked synaptic response of neurons to transcallosal stimuli is severely impaired in cortex containing substantial plaque accumulation, with an average 2.5-fold greater rate of response failure and twofold reduction in response precision compared with age-matched nontransgenic controls. ... results show that plaques disrupt the synchrony of convergent inputs, reducing the ability of neurons to successfully integrate and propagate information. (Stern et al. 2004)

Pathology Alzheimer Show Other

Stage

Question

Claim