Pathological mechanism

Data

Name Protofibrillar intermediates of ABeta change firing pattern of neurons.

Description

Hypothesis Dendritic Hypothesis - K+ current Show Other

Extracelular pathological element Protofibrillar Abeta Show Other

Intracelular pathological element

Pathological action Increases Show Other

Process Neuronal excitibility: EPSPs, action potentials and depolarization Show Other

Process action

Transmitter(s)

Receptor(s)

Channel(s)

Pharmacological Agent

Pharmacological Action

Brain region

Neuron

Cell model Cultured cortical neurons Show Other

Cellular compartment

PubMed ID 10516307

Citation Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. Show Other

AlzWeb

Notes Protofibrils, but not (Light Molecular Weight) Abeta, produced a rapid increase in EPSPs, action potentials, and membrane depolarizations (and neurotoxicity) in cultured neurons from rat embryo brain. (Hartley et al. 1999)

Pathology Alzheimer Show Other

Stage

Question

Claim Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable Show Other A-type K+ channel block makes dendrites more excitable Show Other