This is the ModelDB version of the readme for the model associated
with the paper:

Gurkiewicz M, Korngreen A (2007) A Numerical Approach to Ion Channel
Modelling Using Whole-Cell Voltage-Clamp Recordings and a Genetic
Algorithm PLoS Computational Biology 3(8):e169

Both the model (569 KB ZIP)


http://compbiol.plosjournals.org/archive/1553-7358/3/8/supinfo/10.1371_journal.pcbi.0030169.sd001.zip

and the paper 

http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0030169

are available at the PLoS web site, and there is this copy of the
model also at ModelDB accession number 97759

In order to run the GA you have to install a recent version of NEURON
available from http://www.neuron.yale.edu

Once installed you can auto-launch from ModelDB and start the training algorithm (button press) or

Under linux:
------------

compile the KChannel.mod file using "nrnivmodl" then type

nrngui ga.hoc

Under Windows:
--------------

Run "mknrndll" then double click on the ga.hoc file icon.

Under MAC OS X:
---------------

On the MAC drag and drop the Ga_demo folder onto the mknrndll icon.
Then drag and drop the ga.hoc file onto the nrngui icon.

--------------

When complete (after about 2 hours on a PC) you will see matches for
activation (the blue target curves are on top of the red search
results):


and deactivation


Have fun