<?xml version="1.0"?>
<edsp version="3.1" about_me="http://ycmi.med.yale.edu/EAVCR/EDSP" source="Olfactory Receptors Database">
  <source>
    <type>eav/cr</type>
    <name>Data Store:SenseLab</name>
    <location>itts023d.itts.ttu.edu</location>
    <date>4/10/2026 11:41:35 AM</date>
    <query_method>GET</query_method>
    <query_parameter>o=68309</query_parameter>
  </source>
  <metadata type="partial" time="0.0156245000034687">
    <datatypes>
      <datatype id="B" name="Boolean" xml_datatype="xs:boolean" />
      <datatype id="C" name="Object/Ref" xml_datatype="xs:long" />
      <datatype id="D" name="Datetime" xml_datatype="xs:dateTime" />
      <datatype id="F" name="Formula(only)" xml_datatype="xs:anyType" />
      <datatype id="H" name="Hierarchy(p)" xml_datatype="xs:long" />
      <datatype id="I" name="Integer" xml_datatype="xs:long" />
      <datatype id="M" name="Memo" xml_datatype="xs:string" />
      <datatype id="R" name="Real" xml_datatype="xs:double" />
      <datatype id="S" name="String" xml_datatype="xs:string" />
      <datatype id="V" name="Object/Value" xml_datatype="xs:long" />
      <datatype id="W" name="Object/Ref(MC)" xml_datatype="xs:long" />
      <datatype id="Y" name="Binary" xml_datatype="xs:base64Binary" />
    </datatypes>
    <metadata_ontology>
      <sem_type_atts />
      <sem_rel_types>
        <srt id="s1" umls_tui="QB" name="Class qualifies Attribute" />
      </sem_rel_types>
      <sem_rel_att>
        <sra id="s1" umls_tui="T186" name="is a" />
      </sem_rel_att>
    </metadata_ontology>
    <database id="d14" name="brainpharm" caption="Brain Pharm" caption_long="Brain Pharmacology Database" description="A database to support research on drugs for treatment of different neurological disorders. It enables searches for interactions at the level of key molecular constituents, cell compartments and individual cells in normal brain and in nervous disorders." main_class="108" version="6" version_date="2/23/2009 12:23:48 PM">
      <class id="c107" name="citations" caption="BrainPharm citations" description="BrainPharm citations" object_description_hide="true" type="E" is_concept="false" host_concepts="false" uid="" version="10" version_date="4/4/2008 10:38:27 PM">
        <att id="a369" dt_id="M" sn="1" name="title" caption="Title" description="publication title" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="7/7/2006 11:02:51 PM" />
        <att id="a368" dt_id="M" sn="2" name="authors" caption="Authors" description="" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="1" version_date="7/5/2006 3:46:37 PM" />
        <att id="a351" dt_id="M" sn="3" name="abstract" caption="Abstract" description="Citation's abstract" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="4" version_date="7/7/2006 11:03:18 PM" />
        <att id="a370" dt_id="S" sn="4" name="pubmedid" caption="PubMed ID" description="PubMed's unique number that identifies a journal publication" width="20" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="7/7/2006 12:09:44 PM" />
        <att id="a371" dt_id="S" sn="5" name="volume" caption="Volume" description="" width="20" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="1" version_date="7/5/2006 3:52:58 PM" />
        <att id="a372" dt_id="S" sn="6" name="pages" caption="Pages" description="" width="20" is_concept="false" host_concepts="false" srt_id="s" sra_id="s" version="1" version_date="7/5/2006 3:53:30 PM" />
        <att id="a374" dt_id="S" sn="7" name="year" caption="year" description="Year published" width="6" is_concept="false" host_concepts="false" srt_id="s1" sra_id="s1" version="2" version_date="7/7/2006 11:51:09 AM" />
      </class>
    </database>
  </metadata>
  <data time="0.0156253999957698">
    <data_database db_id="d14">
      <data_class class_id="c107" version="10">
        <object id="o68309" name="12611941" description="" uid="" version="1" version_date="7/11/2006 4:48:03 PM">
          <att_value att_id="a369" value="Nicotine enhances the depressive actions of A beta 1-40 on long-term potentiation in the rat hippocampal CA1 region in vivo." />
          <att_value att_id="a368" value="Freir DB, Herron CE" />
          <att_value att_id="a351" value="Hippocampal long-term potentiation (LTP) is a form of synaptic plasticity used as a cellular model of memory. Beta amyloid (A beta) is involved in Alzheimer's disease (AD), a neurode-generative disorder leading to cognitive deficits. Nicotine is also claimed to act as a cognitive enhancer. A beta is known to bind with high affinity to the alpha 7-nicotinic acetylcholine receptor (nAChR). Here we have investigated the effect of intracerebroventricular (i.c.v.) injection of the endogenous peptide A beta 1-40 on LTP in area CA1 of urethananesthetized rats. We also examined the effect of A beta 12-28 (i.c.v.), which binds with high affinity to the alpha 7-nAChR and the specific alpha 7-nAChR antagonist methyllycaconitine (MLA) on LTP. We found that A beta 12-28 had no effect on LTP, whereas MLA depressed significantly LTP, suggesting that activation of the alpha 7-nAChR is a requirement for LTP. Within the in vivo environment, where other factors may compete with A beta 12-28 for binding to alpha 7-nAChR, it does not appear to modulate LTP. To determine if the depressive action of A beta 1-40 on LTP could be modulated by nicotine, these agents were also co-applied. Injection of 1 or 10 nmol A beta 1-40 caused a significant depression of LTP, whereas nicotine alone (3 mg/kg) had no effect on LTP. Co-injection of nicotine with A beta 1-40 1 h prior to LTP induction caused a further significant depression of LTP compared with A beta 1-40 alone. These results demonstrate that nicotine enhances the deficit in LTP produced by A beta 1-40. This then suggests that nicotine may exacerbate the depressive actions of A beta on synaptic plasticity in AD." />
          <att_value att_id="a370" value="12611941" />
          <att_value att_id="a371" value="89" />
          <att_value att_id="a372" value="2917-22" />
          <att_value att_id="a374" value="2003" />
        </object>
      </data_class>
    </data_database>
  </data>
</edsp>

