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Name
681 STN neurons containing a4ß2 nAChRs (a4ß2 neurons) received more glutamatergic inputs, and preferentially innervated GABAergic neurons in the substantia nigra pars reticulata. In contrast, STN neurons containing a7 nAChRs (a7 neurons) received more GABAergic inputs, and preferentially innervated dopaminergic neurons in the substantia nigra pars compacta."
682 Striatal FSIs make [GABAergic] synapses onto both direct and indirect path- way SPN. The biophysical properties of the synaptic contacts do not differ and exhibit short-term depression. Further, single FSI often make synapses with both types of SPN”
683 Strychnine-sensitive glycine receptors are present on a subpopulation of the cholinergic interneurons in rat caudatoputamen, supporting the hypothesis that (excitatory) glycine receptors inducing striatal release of [(3)H]acetylcholine may be localized to cholinergic neurons
684 Substantial in most deep pyramidal and multipolar cells; generates hyperpolarizing potentials lasting several seconds; as I AHP contributes to rapid spike frequency adaptation; blocked by cholinergic agonists
685 Subthalamic nucleus neurons make glutamatergic connections on neurons of the globus pallidus.
686 Subthalamic nucleus neurons receive input from GABAergic globus pallidus neurons through GABA-A receptors.
687 Subthreshold membrane potential oscillations are blocked by bath application of tetrodotoxin (TTX), a potent Na(t)-current antagonist, in rats 3-17 days old
688 Suggested.
689 suggesting the presence of mGluRs.
690 suggesting the presence of mGluRs.
691 Synapse of type 2
692 Synaptic inhibition of mitral cells: Yamamoto et al, 1962;
693 T-type calcium current recorded in bipolar cells in slice in mouse
694 T-type channels are less dense in the soma than in the dendrites
695 The A current increases with distance from the soma normalizes Ca+ signals during AP propagation
696 The action potential has a pronounced Ca component on its falling phase
697 The amplitude of ensemble K+ currents in cell-attached patches decreased along the apical dendrite as the distance from the soma increased, with a slope of -0.9 +/- 0.3 pA per 100um. In nucleated outside-out patches from soma in acute slices of sensorimotor cortex from 13- to 15-day-old Wistar rats some patches contained only I-A-like channels, other contained only IK-like channels that did not inactivate or inactivated slowly, and the remainder contained mixtures of both types. The amount of IA and IK depended weakly on distance along the primary apical dendrite from the soma. The amplitude of IA increased, while the amplitude of IK decreased
698 the back-propagating action potential may be important for the dendritic release of dopamine"
699 The balance between synaptic (glutamatergic) and non-synaptic conductance indicates that the synapse will not shunt the cell and the conductance ratio serves to maximize incremental gain at the photoreceptor to ON bipolar synapse.
700 The basal conductance of unstimulated frog ORN was investigated using whole-cell and perforated-patch recording. It was found that under physiological conditions, gating of CNG channels contributes approximately 0.06 nS to the resting neuronal conductance
701 The baskets formed by inhibitory basket cells have high concentrations of glutamic acid decarboxylase (GAD), the enzyme that synthesizes GABA
702 The CA1 oblique dendrites (also called radial oblique) are the main target of the Schaffer collaterals from CA3, and are therefore the primary sites of generation of LTP.
703 The cellular localization of GABAB binding was investigated using lesion techniques. It was suggested that the majority of cerebellar molecular layer GABAB binding sites are located on Purkinje cell dendrites. During development binding in the molecular layer peaks between postnatal day 14 and postnatal day 28 and then decreases to adult levels
704 The contribution of a fast (IAt), and a slowly (IAs)-inactivating A-currents were studied in slices. The results suggest a role for these currents to define the limits on the depolarized state
705 The contribution of an inwardly rectifying current (IKir) were studied in slices. The results suggest that the hyperpolarized state is determined principally by this current
706 The developmental evolution of Ca-dependent spikes in the tuft was investigated using simultaneous somatic and dendritic recordings
707 The distribution of GABAA and GABAB receptors was studied with patch-clamp recording in combination with infrared-guided laser stimulation to release GABA photolytically. The data suggest that relatively more GABAA receptors are located at the apical dendrite and relatively more GABAB receptors near the soma
708 The distribution of the P-type calcium channel in the mammalian central nervous system has been demonstrated immunohistochemically by using a polyclonal specific antibody. Electron microscopic localization revealed labeled patches of plasma membrane on the soma, main dendrites, spiny branchlets, and spines; portions of the smooth endoplasmic reticulum were also labeled. Strong labeling was present in the periglomerular cells of the olfactory bulb, ...etc
709 The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors [mGluR1 and mGluR5]” Reviewed in
710 The effects of glutamate on SNr cells is mediated by the three principal types of glutamate receptors: a-amino 3hydroxy-5methyl- 4-isoxaline propionic acid/kainate (AMPA), N-methyl-D aspartate (NMDA) and metabotropic receptors” Reviewed in
711 The effects of intracellular calcium buffering on electrical tuning were studied in hair cells at apical and basal cochlear locations tuned to 100 and 300 Hz. Ca2+ imaging revealed about twice as many hotspots of Ca2+ entry during depolarization in high-frequency compared to low-frequency hair cells. It is suggested that each KCa channel is gated by Ca2+ entry through a few nearby Ca2+ channels, and that Ca2+ and KCa channels occupy, at constant channel density, a greater fraction of the membrane area in high-frequency cells than in low-frequency cells
712 The effects of intracellular calcium buffering on electrical tuning were studied in hair cells at apical and basal cochlear locations tuned to 100 and 300 Hz. High conductance KCa channels were 2-fold less Ca2+ sensitive in high-frequency than in low-frequency cells. It is suggested that each KCa channel is gated by Ca2+ entry through a few nearby Ca2+ channels, and that Ca2+ and KCa channels occupy, at constant channel density, a greater fraction of the membrane area in high-frequency cells than in low-frequency cells
713 The effects of this current on the firing properties were studied in brainstem slices
714 The fast and slow components of EPSCs were studied using whole cell patch clamp recordings
715 The functional properties of AMPA receptors were studied in acute slices. It was found that AMPARs expressed in different types of basal ganglia neurons were markedly diverse
716 The functional properties of NMDA receptors were studied in acute slices. Little variability in functional properties was found in different types of basal ganglia neurons
717 The GABABR1a antibody selectively marked the neuropil in layer Ia, where afferent olfactory fibers and intrinsic GABAergic axons terminate on the distal apical dendrites of pyramidal neurons. GABABR1a may be involved in feedforward synaptic circuits
718 The globus pallidus, a neuronal nucleus involved in the control of motor behavior, expresses high levels of histamine H3 receptors (H3Rs) most likely located on the synaptic afferents to the nucleus.”
719 The GP is mainly made up by two populations of GABAergic neurons, with the predominant one projecting to the subthalamic nucleus while a second group sends projections to the striatum."
720 The kinetic properties of this current have been studied in mice using voltage clamp with whole-cell patch recordings