| 801 |
Using double-staining techniques, the distribution of NADPH-diaphorase (ND)- and nitric oxide synthase (NOS)-positive cells was compared in the periglomerular region of typical and atypical rat olfactory glomeruli. The number of ND/NOS-stained periglomerular cells was much higher (P < 0.001) in typical than in atypical glomeruli. |
| 802 |
Using electrophysiological recordings and imaging, the density of these channels was found to rapidly decrease with distance from soma |
| 803 |
Using electrophysiological recordings and imaging, the density of these channels was found to rapidly decrease with distance from soma and clustered in high density around the base of dendrites |
| 804 |
Using ex vivo slices of guinea pig midbrain, we show that SNr GABAergic neurons express transient receptor potential melastatin 2 (TRPM2) channels that underlie NMDA-induced burst firing. Furthermore, we show that spontaneous firing rate and burst activity are modulated by the reactive oxygen species H(2)O(2) acting via TRPM2 channels. Thus, our results indicate that activation of TRPM2 channels is necessary for burst firing in SNr GABAergic neurons and their responsiveness to modulatory H(2)O(2).” |
| 805 |
Using ex vivo slices of guinea pig midbrain, we show that SNr GABAergic neurons express transient receptor potential melastatin 2 (TRPM2) channels that underlie NMDA-induced burst firing. Furthermore, we show that spontaneous firing rate and burst activity are modulated by the reactive oxygen species H2O2 acting via TRPM2 channels. Thus, our results indicate that activation of TRPM2 channels is necessary for burst firing in SNr GABAergic neurons and their responsiveness to modulatory H2O2.” |
| 806 |
Using in vitro methods, the modulatory actions of 5HT were examined on three different calcium-insensitive K-currents among others |
| 807 |
Using intra- and extracellular recordings in ferret it has been shown that these neurons interact locally through the activation of GABA-A receptor-mediated inhibitory potentials |
| 808 |
Using outside-out patches and a fast application system the properties and distribution of synaptic glutamate receptors an approximately twofold increase in AMPA-mediated current was observed in the dendritic region that receives a uniform density of Schaffer collateral input (100-250um from soma) |
| 809 |
Using radioactive in situ hybridization methods, heavy labeling for NMDAR1 subunit was observed in all major CN neuronal types with lower labeling for NMDAR2A, 2B, 2C, and 2D mRNA |
| 810 |
using whole-cell patch-clamp recordings from freshly dissociated mouse neocortical pyramidal neurons showed that Ca2+-dependent K+ currents were activated by Ca2+ entry through both N- and L-type channels |
| 811 |
Using whole-cell recordings, the kinetic properties of this current have been investigated in neurones from neonatal rats, which were retrogradely labelled and identified after enzymatic dissociation |
| 812 |
Variable densities of active channels support variable extents of backpropagating impulse in the dendrites |
| 813 |
Voltage-clamp analysis suggested that IAHP in DG neurones is generated by about 1200 channels, and that about 60% are open at the peak of a maximal IAHP |
| 814 |
Voltage-dependent Ca currents are seen in isolated bipolar cells |
| 815 |
Voltage-gated sodium channels were found throughout the whole dendritic tree of GP neurons, and showed a significant clustering at sites of excitatory synaptic inputs.” |
| 816 |
Voltage-sensitive dye signals recorded from the glomerular layer reflect activity in periglomerular cells and that Cl- efflux through non-GABAA chloride channels contributes to the postsynaptic depolarization of these cells after olfactory nerve stimulation |
| 817 |
We find that small-conductance Ca2+-activated K+ (SK) channels underlie most of the mAHP in GP neurons. This mAHP conductance is a small component of the overall outward current that flows during the subthreshold part of the oscillatory cycle, the majority of which is provided instead by an inactivating K+ current." |
| 818 |
Whereas, activation of the adenosine A1 receptor reduces synaptic strength by modulating presynaptic calcium channels, baclofen modulates presynaptic calcium channels as well, but also affects release processes downstream from calcium entry |
| 819 |
which is important for the induction of long term changes in synaptic strength" |
| 820 |
While nicotinic and muscarinic acetylcholine receptors exist in FSI-SPN synapses, only the nicotinic receptors are postsynaptic. |
| 821 |
While NMDA receptor activation may be necessary for LTP at the commissural/associational synapses |
| 822 |
Whole cell and perforated patch recordings in slices showed bicuculline-dependent and ?independent GABA currents from juvenile rats, suggesting two types of GABAergic inputs. The bicuculline-independent component was present only at the earliest stages of maturation, had a later peak, slower time course of decay, and marked outward rectification. A trophic or signaling role rather than primarily inhibitory was suggested for this current |
| 823 |
Whole cell recording experiments have revealed a sustained, partially nimodipine-sensitve current in steps to -50mV, suggesting that they play a role in CA2+ signalling at low voltages as well as a their classical high voltages |
| 824 |
Whole cell recording experiments have revealed a sustained, partially nimodipine-sensitve current in steps to -50mV, suggesting that they play a role in CA2+ signalling at low voltages as well as a their classical high voltages |
| 825 |
Whole cell recording from acutely isolated rat CA3 pyramidal neurons revealed a transient (59 msec decay time constant) that was inhibited by Ni2+ and amiloride |
| 826 |
Whole cell recordings from acutely dissociated neurons exhibited a R-type currents that were characterized as HVA by their rapid deactivation kinetics, half-activation and half-inactivation voltages, and sensitivity to depolarized holding potentials. In neocortical pyramidal neurons these currents inactivated at more negative potentials than in medium spiny neurons |
| 827 |
Whole-cell and cell-attached patch-clamp recordings showed that ACh activates apamin-sensitive, "SK"-type potassium channels |
| 828 |
Whole-cell patch-clamp recording of ICa from presynaptic boutons are comparable to that obtained from somatic recordings, but elevation of intracellular Ca is restricted to the presynaptic terminals, with no somatic or axonal changes observed |
| 829 |
Whole-cell patch-clamp recordings showed that variations in the kinetics of the outward current contribute substantially to the determination of resonant frequency |
| 830 |
Whole-cell patch-clamp recordings were used to identify and characterize ionic currents in isolated cells. All hair cells possessed an IKCa |
| 831 |
Whole-cell patch-clamp recordings were used to identify and characterize ionic currents in isolated cells. In a small subset of cells, the IK was replaced by an IA. It is suggested that the kinetic properties of the ionic currents argue against electrical tuning |
| 832 |
Whole-cell patch-clamp recordings were used to identify and characterize ionic currents in isolated cells. Most cells possessed a slowly activating IK, which is approximately 80% inactive at rest. In a small subset of cells, IK was replaced by an IA. It is suggested that the kinetic properties of the ionic currents argue against electrical tuning |
| 833 |
Whole-cell patch-clamp recordings were used to identify and characterize ionic currents in isolated cells. Most cells possessed an Ih, which actively contributed to the resting potential |
| 834 |
Whole-cell somatic recording during TTX application to proximal dendrites suggests the presence of a persistent Na current |
| 835 |
Whole-cell voltage-clamp recordings showed that a low-threshold transient (T-type) Ca2+ current was observed in 40% of neurons |
| 836 |
Whole-cell voltage-clamp recordings showed that HVA currents were present in at least 95% of neostriatal neurons, but that the majority of them appeared to belong neither to the "L-type" nor the "N-type" classification |
| 837 |
With a postembedding immunogold procedure, it has been found that these receptors do not appear to be concentrated in clusters on dendrites, suggesting that the presynaptic effects of glutamate are mediated by a small complement of extrasynaptic receptors |
| 838 |
With whole-cell patch clamp, two types of A-current were found in rat neostriatal neurons, one similar to previous descriptions in mammals and a second activated at considerably more depolarized potentials |
| 839 |
With whole-cell recordings the properties of a voltage-dependent Na+ currents were investigated in 42 DGC acutely isolated from the resected hippocampus of 20 patients with therapy-refractory temporal lobe epilepsy (TLE) using the whole-cell patch-clamp technique.The kinetic properties contributed to a reduction of the Na+ currents during repetitive stimulation that was more pronounced with higher stimulation frequencies and also showed a dependence on the holding potential |
| 840 |
Young and Oertel, in |
