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Glu from Ia axon terminals (reviewed in Show
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Intracellular recordings: CMQX and NBQX applied at the soma completely block short duration (i.e. near soma) single fiber EPSPs Show
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see Burke 1998 for references). Single-fiber Ia EPSPs have widely varying shapes Show
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indicating that Ia synapses are distributed widely over soma-dendrites (confirmed by HRP labelling of Ia afferents on labelled motoneurones: reviewed in Show
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SOBiv p88). Glutamate is released from Ia terminals Show
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Ia synapses are immunoreactive for GLU Show
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Ia EPSPs are mediated largely by AMPA receptors (muscle afferents: Show
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single fiber EPSPs: Show
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by contrast, Show
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found an NMDA component in neonatal rat. Short-term post-tetanic potentiation (PTP) and depression (PTD) occur Show
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but not LTP or LTD (SOBiv p90).Motoneurons have a high density of AMPA receptors (Vandenberghe et al, JNS 20: 7158, 2000). There is evidence that "glutamate receptor-mediated Ca2+ influx, intracellular Ca2+ accumulation, and subsequent cell death" may be involved in the mechanism of selective motoneuron degeneration in amyotrophic lateral sclerosis. Show
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