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Cells were voltage-clamped using a single microelectrode, at 23-30 degrees C. M-current resembled that of sympathetic ganglion cells. It was abolished by addition of carbachol, muscarine or bethanechol, as well as by 1 mM barium. It was suggested that activation of cholinergic septal inputs to the hippocampus facilitates repetitive firing of pyramidal cells by turning off the M-conductance, without much change in the resting potential of the cell Show
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It was was blocked by linopirdine in a reversible, concentration-dependent manner Show
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and by cholinergic agonists in slices Show
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Serotonin produced a slowly developing and long-lasting suppression of IM leading to depolarization end excitation Show
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It was decreased by cannabinoids Show
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