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Ih conductance causes voltage attunuation and is more concentrated in dendrites than in soma Show
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The subcellular distribution and biophysical properties of this current were studied in cell-attached patches. Up to approximately 400um from the soma a low density of channels was found, with a 20-fold increase in the apical distal dendrite. The findings suggest that integration of synaptic input to the apical tuft and the basal dendrites occurs spatially independently due to the high Ih channel density in the apical tuft that increases the electrotonic distance between these two compartments in comparison to a passive dendrite Show
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A linear increase has been found (9 pA/100um) in the density of these channels with distance from soma. It was suggested that this generates site independence of EPSP time course Show
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