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The effects of intracellular calcium buffering on electrical tuning were studied in hair cells at apical and basal cochlear locations tuned to 100 and 300 Hz. High conductance KCa channels were 2-fold less Ca2+ sensitive in high-frequency than in low-frequency cells. It is suggested that each KCa channel is gated by Ca2+ entry through a few nearby Ca2+ channels, and that Ca2+ and KCa channels occupy, at constant channel density, a greater fraction of the membrane area in high-frequency cells than in low-frequency cells Show
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Whole-cell and cell-attached patch-clamp recordings showed that ACh activates apamin-sensitive, "SK"-type potassium channels Show
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Whole-cell patch-clamp recordings were used to identify and characterize ionic currents in isolated cells. All hair cells possessed an IKCa Show
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Using a whole chick (Gallus domesticus) basilar papilla preparation, a map of changes in potassium currents of tall hair cells was produced. All cells recorded from expressed IKCa and IK. The amplitude of total outward current increased in a gradient along the tonotopic axis Show
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Whole-cell patch-clamp recordings showed that variations in the kinetics of the outward current contribute substantially to the determination of resonant frequency Show
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