OrDB
Neuron
  Data
Dentate gyrus granule GLU cell
Lomo, Patterns of activation in a monosynaptic cortical pathway: The perforant path input to the dentate area of the hippcampal formation, Experimental Brain Research, 1971 12:46-63.
90
399,122
The principal neuron of the fascia dentata of the hippocampal region. It forms a single layer of cell bodies. Each cell has a dendritic tree that extends toward the surface. The branches are covered with dendritic spines. The input is carried by axons which arise in the nearby entorinal cortex and "perforate" the intervening cortex to make excitatory glutamatergic synapses onto the spines. The output is carried in an axon which becomes a mossy fiber as it arrives in CA3 and CA2 of the hippocampus to make glutamatergic synapes onto the spinous excrecenses of hippocampal pyramidal cells in those regions.
66
 Neuronal Receptors (23)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Distal equivalent dendrite NMDA Perforant path terminals
2 Yes Distal equivalent dendrite AMPA Perforant path terminals
3 Yes Distal equivalent dendrite mGluR Perforant path terminals
4 Yes Distal equivalent dendrite GabaA Hilar spiny interneuron terminals
5 Yes Distal equivalent dendrite GabaB Hilar spiny interneuron terminals
6 Yes Middle equivalent dendrite AMPA Perforant path terminals
7 Yes Middle equivalent dendrite mGluR Perforant path terminals
8 Yes Middle equivalent dendrite GabaA Hilar spiny and aspiny interneuron terminals
9 Yes Middle equivalent dendrite NMDA Perforant path terminals
10 Yes Middle equivalent dendrite GabaB Hilar spiny and aspiny interneuron terminals
11 Yes Proximal equivalent dendrite NMDA Hilar mossy cell collaterals and commissural cell terminals
12 Yes Proximal equivalent dendrite GabaB Hilar aspiny interneuron terminals
13 Yes Proximal equivalent dendrite mGluR Hilar mossy cell collaterals and commissural cell terminals
14 Yes Proximal equivalent dendrite AMPA Hilar mossy cell collaterals and commissural cell terminals
15 Yes Proximal equivalent dendrite GabaA Hilar aspiny interneuron terminals
16 Yes Axon hillock GabaA Chandelier cell terminals
17 Yes Axon hillock GabaB Chandelier cell terminals
18 Yes Soma GabaA Basket cell terminals Whole cell and perforated patch recordings in slices showed bicuculline-dependent and ?independent GABA currents from juvenile rats, suggesting two types of GABAergic inputs. The bicuculline-independent component was present only at the earliest stages of maturation, had a later peak, slower time course of decay, and marked outward rectification. A trophic or signaling role rather than primarily inhibitory was suggested for this current
19 Yes Soma AMPA NMDA and AMPA conductances properties were studied using patch-clamp recordings in morphologically identified cells in slices prepared from surgically removed medial temporal lobe specimens of epileptic patients (14 specimens from 14 patients
20 Yes Soma NMDA NMDA and AMPA conductances properties were studied using patch-clamp recordings in morphologically identified cells in slices prepared from surgically removed medial temporal lobe specimens of epileptic patients (14 specimens from 14 patients). The wide range of changes in the slope conductance of the NMDA EPSCs suggests that the NMDA-receptor-mediated conductance could be altered in human epileptic DGCs
21 Yes Soma GabaB Basket cell terminals
22 Yes Soma Nicotinic
23 Yes Axon terminal Kainate It has been shown that activation of these receptors could facilitate transmitter release. Their activation is very fast (<10 ms) and lasts for seconds, and could contribute to the short-term plasticity characteristics of mossy fiber synapses
 Neuronal Currents (23)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Distal equivalent dendrite I Na,t
2 Yes Distal equivalent dendrite I A
3 Yes Distal equivalent dendrite I L high threshold
4 Yes Distal equivalent dendrite I Na,p low density
5 Yes Middle equivalent dendrite I L high threshold
6 Yes Middle equivalent dendrite I Na,p low density
7 Yes Proximal equivalent dendrite I L high threshold
8 Yes Proximal equivalent dendrite I Na,p
9 Yes Axon hillock I K
10 Yes Axon hillock I Na,t
11 Yes Axon hillock I K,Ca
12 Yes Axon terminal I N
13 Yes Soma I K,Ca Voltage-clamp analysis suggested that IAHP in DG neurones is generated by about 1200 channels, and that about 60% are open at the peak of a maximal IAHP
14 Yes Soma I L high threshold Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats
15 Yes Soma I N Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats
16 Yes Soma I T low threshold Patch-clamp recordings from human cells showed N-type, L-type and T-type currents that had similar pharmacological and kinetic characteristics as in control rats. The current density was significantly larger in human and in the kainate model compared to cells isolated from adult control rats
17 Yes Soma I A The properties of outward currents were investigated with patch-clamp in acutely isolated cells at various postnatal ages and at adulthood (2-3 mo). Kinetic analysis and pharmacological properties showed that IK and IA were present in these cells. IA and IK remained stable with respect to kinetic properties during ontogenesis, but the relative contribution and pharmacological properties varied with age. IA dominated in P5-7 cells whereas IK was prominent in most older cells
18 Soma I h Patch-pipette recordings found no evidence for a ?sag? in hyperpolarizing responses, suggesting that this current is not present in these neurons
19 Yes Middle equivalent dendrite I Na,t Indirect experimental evidence for dendritic Na channels was suggested by laminar filed potential studies
20 Yes Proximal equivalent dendrite I Na,t Indirect experimental evidence for dendritic Na channels was suggested by laminar filed potential studies
21 Yes Soma I Na,t The kinetic properties of this current were studied using the whole-cell voltage-clamp method in acutely isolated cells. No significant differences were found after induction of status epilepticus
22 Yes Soma I K The properties of outward currents were investigated with patch-clamp in acutely isolated rat DGCs at various postnatal ages and at adulthood (2-3 mo). Kinetic analysis and pharmacological properties showed that IK and IA were present in these cells. IA and IK remained stable with respect to kinetic properties during ontogenesis, but the relative contribution and pharmacological properties varied with age. IA dominated in P5-7 cells whereas IK was prominent in most older cells
23 Yes Axon terminal I L high threshold Transients and kinetics for these channels were studied using whole-cell patch clamp recordings
 Neuronal Transmitters (6)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Axon terminal Zn2+ CA3 pyramidal neuron proximal dendrites, mossy cell proximal dendrites, and basket cell basal dendrites
2 Yes Axon terminal Glutamate CA3 pyramidal neuron proximal dendrites, mossy cell proximal dendrites, and basket cell basal dendrites
3 Yes Axon fiber Glutamate To presynaptic kainate receptors in the CA3 region of the hippocampus Glutamate - kainate receptor (glur6)In mouse hippocampal slices, bath application of kainate caused presynaptic reduction in epscs at mossy fiber synapses on CA3 pyramidal cells in glur6 knockouts but not in glur5 knockouts.
4 Yes Middle equivalent dendrite Dynorphin Perforant path terminals
5 Yes Distal equivalent dendrite Dynorphin Perforant path terminals
6 Yes Axon terminal Dynorphin CA3 pyramidal neuron proximal dendrites, mossy cell proximal dendrites, and basket cell basal dendrites
Other categories referring to Dentate gyrus granule GLU cell
Pathological mechanism.Neuron   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Neural compartmental intracell.Neuron   (1)
Cell Type.NeuronDB Neuron   (1)
Neuronal Structure.Neurons   (1)
ICG channel details.ICG ModelDB cell   (3)
Revisions: 13
Last Time: 12/18/2015 11:13:46 AM
Reviewer: System Administrator
Owner: System Administrator