OrDB
Neuron
  Data
Olfactory bulb main interneuron granule MC GABA cell
Cajal (1911) Histology of the Nervous System of Man and Vertebrates (p536, English translation, 1995)
268,201
Olfactory bulb mitral cell granule cell (see Mori 1987 Prog Neurobiol. 1987;29(3):275-320 for three types of granule cells)
128
 Neuronal Receptors (32)
  
SN Property present CF-Compartment Receptor Connect Note Publication facts
1 Yes Distal equivalent dendrite Cholinergic Receptors from basal forebrain Choline acetyltransferase immunocytochemistry shows that cholinergic projections from the basal forebrain to the main olfactory bulb focus synaptic innervation on interneurons, on the dendritic spines of periglomerular and granule cells.
2 Yes Distal equivalent dendrite Muscarinic basal forebrain Activation of muscarinic receptors decreases granule cell firing frequency, as well as modulates GABAergic synaptic inputs onto mitral cells.
3 Yes Soma Muscarinic basal forebrain Activation of muscarinic receptors decreases granule cell firing frequency, as well as modulates GABAergic synaptic inputs onto mitral cells.
4 Yes Soma Cholinergic Receptors from basal forebrain Choline acetyltransferase immunocytochemistry shows that cholinergic projections from the basal forebrain to the main olfactory bulb focus synaptic innervation on interneurons, on the dendritic spines of periglomerular and granule cells.
5 Yes Middle equivalent dendrite GabaB It has been suggested in rats that GABA(B) receptors modulate dendrodendritic inhibition primarily by inhibiting granule cell calcium channels and reducing the release of GABA
6 Yes Distal equivalent dendrite GabaB It has been suggested in rats that GABA(B) receptors modulate dendrodendritic inhibition primarily by inhibiting granule cell calcium channels and reducing the release of GABA
7 Yes Distal equivalent dendrite mGluR5 Activation of mGluR5 increases GC excitability, an effect that should increase GC-mediated GABAergic inhibition of mitral cells
8 Yes Soma mGluR Activation of mGluR increases GC excitability, an effect that should increase GC-mediated GABAergic inhibition of mitral cells
9 Yes Middle equivalent dendrite Alpha1 High concentration of NE acts at Alpha1 receptors to increase GC excitability and increase GABAergic inhibition inhibition of MC
10 Yes Proximal equivalent dendrite mGluR5 Activation of mGluR5 increases GC excitability, an effect that should increase GC-mediated GABAergic inhibition of mitral cells
11 Yes Middle equivalent dendrite mGluR Activation of mGluR increases GC excitability, an effect that should increase GC-mediated GABAergic inhibition of mitral cells
12 Yes Soma Nicotinic culture cells Application of acetylcholine (ACh) evoked concentration-dependent whole-cell currents
13 Yes Soma Alpha1 from Locus coeruleus High concentration of NE acts at Alpha1 receptors to increase GC excitability and increase GABAergic inhibition inhibition of MC
14 Yes Soma mGluR5 Activation of mGluR5 increases GC excitability, an effect that should increase GC-mediated GABAergic inhibition of mitral cells
15 Yes Proximal equivalent dendrite Alpha2 High concentration of NE acts at Alpha2 receptors to decrease GC excitability and decrease GABAergic inhibition inhibition of MC
16 Yes Middle equivalent dendrite mGluR5 Activation of mGluR5 increases GC excitability, an effect that should increase GC-mediated GABAergic inhibition of mitral cells
17 Yes Distal equivalent dendrite mGluR Activation of mGluR increases GC excitability, an effect that should increase GC-mediated GABAergic inhibition of mitral cells
18 Yes Soma Kainate In an immunocytochemical study in zebrafish 60-70% of cells showed KA receptor mediated labelling
19 Yes Distal equivalent dendrite NMDA from mitral cell Calcium influx through NMDA receptors directly evokes GABA release in granule cells.
20 Yes Proximal equivalent dendrite mGluR Activation of mGluR increases GC excitability, an effect that should increase GC-mediated GABAergic inhibition of mitral cells
21 Yes Soma Glycine study in primary culture Glycine and GABA elicit concentration-dependent desensitizing currents mediated by chloride.
22 Yes Soma GabaA primary culture Cell-specifc modulation of GABAA receptor- mediated chloride current by dopamine. In interneurons (mainly granule cells), dopamine reduces GABAA Cl- current, via D1 receptor and involves phosphorylation of GABAA receptors by PKA. In mitral cell, dopamine enhances GABA responses via activation of D2 receptors and phosphorylation of GABAA receptors via PKC.
23 Yes Soma Dopaminergic Receptor primary culture Cell-specifc modulation of GABAA receptor- mediated chloride current by dopamine. In interneurons (mainly granule cells), dopamine reduces GABAA Cl- current, via D1 receptor and involves phosphorylation of GABAA receptors by PKA. In mitral cell, dopamine enhances GABA responses via activation of D2 receptors and phosphorylation of GABAA receptors via PKC.
24 Yes Distal equivalent dendrite Gaba mitral (or tufted) cell There is a selective localization of GABA receptors at symmetric synaptic junctions and of glutamate receptors at asymmetric junctions
25 Yes Proximal equivalent dendrite GabaB It has been suggested in rats that GABA(B) receptors modulate dendrodendritic inhibition primarily by inhibiting granule cell calcium channels and reducing the release of GABA
26 Yes Distal equivalent dendrite AMPA mitral (or tufted) cell DDI (dendrodendritic inhibition) can be elicited by activation of AMPA receptors, while NMDA receptor activation is not an absolute requirement. DDI is blocked by Cd and toxins to N- and P/Q-type channels.
27 Yes Soma NMDA In an immunocytochemical study in zebrafish all cells resulted in NMDA receptor mediated labelling
28 Yes Soma Alpha2 from locus coeruleus High concentration of NE acts at Alpha2 receptors to decrease GC excitability and decrease GABAergic inhibition inhibition of MC
29 Yes Distal equivalent dendrite Alpha1 High concentration of NE acts at Alpha1 receptors to increase GC excitability and increase GABAergic inhibition inhibition of MC
30 Yes Proximal equivalent dendrite Alpha1 from locus coeruleus High concentration of NE acts at Alpha1 receptors to increase GC excitability and increase GABAergic inhibition inhibition of MC
31 Yes Distal equivalent dendrite Alpha2 High concentration of NE acts at Alpha2 receptors to decrease GC excitability and decrease GABAergic inhibition inhibition of MC
32 Yes Middle equivalent dendrite Alpha2 High concentration of NE acts at Alpha2 receptors to decrease GC excitability and decrease GABAergic inhibition inhibition of MC
 Neuronal Currents (13)
  
SN Property present CF-Compartment Current Connect Note Publication facts
1 Yes Middle equivalent dendrite I T low threshold Low threshold calcium spikes were antagonized by T-channel blockers in rat
2 Yes Soma I T low threshold Low threshold calcium spikes were antagonized by T-channel blockers in rat
3 Yes Proximal equivalent dendrite I h histology experiments found Ih in granule cells.
4 Yes Distal equivalent dendrite I p,q Dendrodendritic inhibition (DDI) between mitral and granule cells relies on N-and P/Q- type calcium channels. Magnitude of DDI is proportional to dendritic calcium influx.
5 Yes Distal equivalent dendrite I N Dendrodendritic inhibition between mitral and granule cells involves N-and P/Q- type calcium channels. The magnitude of DDI is proportional to dendritic calcium influx.
6 Yes Middle equivalent dendrite I h histology experiments found Ih in granule cells.
7 Yes Proximal equivalent dendrite I T low threshold Low threshold calcium spikes were antagonized by T-channel blockers in rat
8 Yes Distal equivalent dendrite I A A-channel regulates timing of dendrodendritic inhibition between mitral and granule cells: The transient IA attenuates dendrodendritic input mediated by fast-acting AMPA receptors, such that the excitation and subsequent inhibitory output of granule cells follows the prolonged kinetics of their NMDA receptors. Altering weights of AMPA and NMDA inputs by modulating IA provides a mechanism to regulate the timing of inhibition. A-channels are localized in dendrites.
9 Yes Soma I A mRNA of A-channel subunit Kv4.2 is expressed predominantly in granule cells. (In contrast, that of Kv4.3, also of A-channel, is expressed predominantly in periglomerular cells)
10 Yes Distal equivalent dendrite I T low threshold Low threshold calcium spikes were antagonized by T-channel blockers in rat
11 Yes Soma I CAN This current was studied by combining intracellular recordings and two-photon microscopy imaging of [Ca]i
12 Yes Soma I h histology experiments found Ih in granule cells.
13 Yes Distal equivalent dendrite I h histology experiments found Ih in granule cells.
 Neuronal Transmitters (3)
  
SN Property present CF-Compartment transmitter Connect Note Publication facts
1 Yes Soma Gaba GAD-positive staining
2 Yes Distal equivalent dendrite Gaba onto mitral cell to exert self inhibition or lateral inhibition Selective localization of GABA receptors at symmetric synapses ( and of gluR at asymmetric synapses.)
3 Yes Distal equivalent dendrite NO mitral cells Nitric oxide, released from both mitral and granule cells, is involved in olfactory memories and may act as a retrograde and/or intracellular messenger. However, only mitral cells expressed guanylyl cyclase subunits.
Other categories referring to Olfactory bulb main interneuron granule MC GABA cell
Interneurons Connectivity.Interneuron   (1)
2 Objects Relationship (edge).Object Two (target)   (1)
Neuronal Structure.Neurons   (1)
Revisions: 11
Last Time: 12/18/2015 2:49:29 PM
Reviewer: Luis Marenco
Owner: Buqing Mao