-
Neostriatal cholinergic interneurons fire irregularly but tonically in vivo. The summation of relatively few depolarizing potentials and their temporal sequence are thought to underlie spike triggering and the irregularity of action potential timing, respectively Show
Other
-
Show
Other
-
In vitro, however, blocade of AMPA, NMDA, GABAA,D1 , D2, muscarinic receptors affect little the firing frequencies and patterns of cholinergic interneurons, indicating that these neurons are endogenously active and generate action potentials in the absence of any synaptic input Show
Other
-
Spontaneous firing was driven by the combined action of a sodium current and the hyperpolarization-activated cation current (I(h)), which together ensured that there was no zero current point in the subthreshold voltage range. Spike-triggered calcium entry shaped the falling phase of the action potential waveform and activated calcium-dependent potassium channels Show
Other
|
