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Brain Pharm
Brain Pharmacology Database
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Pathological mechanism (s)
having
Dendritic Hypothesis - Ca++ currents
as
Hypothesis
Name
1
beta Amyloid increases calcium currents
2
beta Amyloid increases calcium currents (2)
3
beta-Amyloid activates I_L by MAP Kinase
4
beta-Amyloid potentiates Ca influx through L-type Ca channels
5
Okadaic acid mediates tau phosphorylation via L channel activation
6
p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
7
Postsynaptic calcium concentration in aging neurons is closely associated with altered plasticity.
8
Presenilin-1 deficient neurons have increased activity of L channels