Neuronal or synaptic activity, especially the reception of neuromodulators can change properties, such as activation, inactivation curves, time constants, and conductances/conductance densities of intrinsic voltage-gated currents. See <a href="http://www.scholarpedia.org/article/Intrinsic_plasticity">http://www.scholarpedia.org/article/Intrinsic_plasticity</a>
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