OrDB

Pathological mechanism - List


 
Name
41 Co-localization of amyloid beta and tau in Alzheimer's disease synaptosomes.
42 DHA increases dendritic spines and synapses; enhanced by uridine and choline
43 Donepezil modulates potassium channels
44 Drebrin decrease causes cognitive deficits but does not affest spatial memory
45 Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease
46 Galantamine increases dopamine release in the hippocampus
47 Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.
48 Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.
49 Histidine associating compounds block Abeta Channel activity and cytotoxicity
50 Inhibition of I_L impairs LTP in CA1 in vivo
51 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice
52 LTP requires BDNF and is associated with cytoskeleton-associated protein
53 Memantine reduces APP, Galantamine and Nicotine increase synaptophysin
54 Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist
55 Model block of I_A
56 Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD
57 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla
58 Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline
59 NGF restores dendritic spine density in Layer V pyramidal neurons
60 Nicotine decreases intracellular copper concentration; attenuates Abeta toxicity
61 Nicotine decreases intracellular Cu+2 concentration. Abeta increases.
62 Nicotine desensitize alpha7 nACh receptors and facilitates LTP
63 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo
64 Nicotine increases APP and APLP2 gene expression
65 Okadaic acid mediates tau phosphorylation via L channel activation
66 p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro
67 Phosphatidyl serine (BC-PS) decreases dendritic spine loss
68 Picomolar concentrations of abeta monomers disrupt LTP
69 Post-synaptic Drebrin correlated with Alzheimer's cognitive decline
70 Postsynaptic calcium concentration in aging neurons is closely associated with altered plasticity.
71 Presenilin-1 deficient neurons have increased activity of L channels
72 Protective effect of donepezil against beta amyloid neurotoxicity
73 Protofibrillar intermediates of ABeta change firing pattern of neurons.
74 Regulation of back-propagating action potentials in hippocampal neurons.
75 Serum magnesium level correlates with clinical deterioration in Alzheimer's
76 Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice
77 Synapse Loss correlated with cognitive loss in mild Alzheimer's Disease
78 Synaptic integration is disrupted in an AD mouse model
79 The channel hypothesis of Alzheimers disease